Responsiveness of FGF-23 and mineral metabolism to altered dietary phosphate intake in chronic kidney disease (CKD)

Research by: Mhairi Sigrist(1), Mila Tang(1), Monica Beaulieu(1,2), Gabriella Espino-Hernandez(2), Lee Er(2), Ognjenka Djurdjev(2) and Adeera Levin (1,2) of (1) the Division of Nephrology, The University of British Columbia, Vancouver, British Columbia, Canada, (2) Statistics and Methodology, BC Provincial Renal Agency, British Columbia, Canada.

Journal: Nephrology Dialysis Transplantation

FGF-23 is a fibroblast growth factor involved in phosphate metabolism and regulation of plasma phosphate levels. Elevations in FGF-23 in CKD and ESRD patients have been linked to worse outcomes. This carefully conducted dietary intervention study demonstrates the ability of a low phosphate diet to lower FGF-23 levels in a CKD population as well as healthy controls and informs future research into potential clinical benefit of targeting lower FGF-23 levels in CKD.

Responsiveness of FGF-23 and mineral metabolism to altered dietary phosphate intake in chronic kidney disease (CKD) (PDF)