Research Publications

Recently published research from the Division of Nephrology.


Remembering the forgotten non-communicable diseases

The forthcoming post-Millennium Development Goals era will bring about new challenges in global health. Low- and middle-income countries will have to contend with a dual burden of infectious and non-communicable diseases (NCDs). Some of these NCDs, such as neoplasms, COPD, cardiovascular diseases and diabetes, cause much health loss worldwide and are already widely recognised as doing so. However, 55% of the global NCD burden arises from other NCDs, which tend to be ignored in terms of premature mortality and quality of life reduction. Here, experts in some of these ‘forgotten NCDs’ review the clinical impact of these diseases along with the consequences of their ignoring their medical importance, and discuss ways in which they can be given higher global health priority in order to decrease the growing burden of disease and disability. Read more...


BC Kidney Days

BC Kidney Days 2013 takes place on October 24 and 25th at the Sheraton Wall Centre in Vancouver. Members of UBC's Division of Nephrology are leading a number of the sessions at this year's conference. Read more...


Quantification of the Early Risk of Death in Elderly Kidney Transplant Recipients

As our ESRD population ages, care strategies need to be reassessed to optimize care across the spectrum of our patients. This study sheds light on the risks and benefits of transplantation in patient > 65 year old. Examining outcomes of standard and extended criteria cadaveric transplantation as well as low and intermediate risk living donor transplantation the study demonstrates differences in long term survivial with living donation providing superior outcomes in patients > 65. These data show the need for future research into ways to minimize mortality risk in this population as well as providing important information to inform patients in transplantation decision making. Read more...


Responsiveness of FGF-23 and mineral metabolism to altered dietary phosphate intake in chronic kidney disease (CKD)

This carefully conducted dietary intervention study demonstrates the ability of a low phosphate diet to lower FGF-23 levels in a CKD population as well as healthy controls and informs future research into potential clinical benefit of targeting lower FGF-23 levels in CKD. Read more...


Optimizing AVF creation prior to dialysis start: the role of predialysis renal replacement therapy choices

This interesting study of BC patients examined all patients starting dialysis over a two-year period to explore the role of pre-dialysis modality choice on AVF creation rates prior to dialysis start. The authors demonstrated nearly half of all dialysis starts did not have a prior modality choice understandably leading to lower AVF creation rates. Additionally, of those who did choose PD first the presence of cardiovascular disease and lower serum albumin levels correlated with starting HD instead and consequently lower AVF creation rates before dialysis start. This study informs future research to identify factors that impact on patient modality selection to better guide predialysis education and modality choice and optimize most appropriate modality selection and access creation. Read more...


Poor seroprotection but allosensitization after adjuvanted pandemic influenza H1N1 vaccine in kidney transplant recipients

Immunization is impaired in immunosuppressed individuals. This study demonstrated a dramatic impact of routine post-transplant immunosuppression on seroprotection after pH1N1 vaccination leaving approximately 2/3 without seroprotection. Importantly, 11.9% of vaccinated patients demonstrated new anti-HLA antibodies post vaccination. The authors inform future research into how to improve seroprotection without adversely affecting HLA antibody formation. Read more...


Income of living kidney donors and the income difference between living kidney donors and their recipients in the United States

In the June 2012 issue of the American Journal of Transplantation, the authors investigate the income differences between living kidney donors and their recipients in the United States. Read more...


Combination hemodialysis and centrifugal therapeutic plasma exchange

Authors Myriam Farah, Adeera Levin, Mercedeh Kiaii, Linda Vickers and Ron Werb report on combination hemodialysis and therapeutic plasma exchange treatments in Hemodialysis International. Read more...


The new Research Agenda and Public Health interface: a framework for improving care

Adeera Levin and Francesco Locatelli, provide an editorial comment as Guest Editors of the July 3, 2012 online edition of Nephrology Dialysis and Transplantation. Read more...


On Being Better Kidney Doctors

An editorial by Adeera Levin, UBC Nephrology Division Head and Ognjenka Djurdjev of the BC Renal Agency from the American Journal of Kidney Disease. Read more...


 

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